Natural Arctium lappa fruit extract improves the clinical signs of aging skin
Anja Knott 1, Katja Reuschlein, Heiko Mielke, Ursula Wensorra, Christopher Mummert, Urte Koop, Martina Kausch, Ludger Kolbe, Nils Peters, Franz Stäb, Horst Wenck, Stefan Gallinat
Background: Subclinical, chronic tissue inflammation involving the generation of cytokines (e.g., interleukin-6 and tumor necrosis factor-alpha) might contribute to the cutaneous aging process.
Aims: This study aims to screen for an active ingredient with anti-inflammatory (i.e., reduction of interleukin-6 and tumor necrosis factor-alpha) and matrix-stimulating efficacy which improves the clinical signs of skin aging in vivo.
A. lappa fruit extract-containing formulation for 12 weeks significantly stimulated procollagen synthesis and increased hyaluronan synthase-2 expression as well as hyaluronan levels compared to vehicle-treated control areas. Similarly, after a 4-week treatment with an A. lappa fruit extract-containing formulation, wrinkle volume in the crow’s feet area was significantly reduced as compared to treatment with the vehicle.
B. Conclusions: Our data show that topical treatment with a natural A. lappa fruit extract significantly improves the metabolism of the dermal extracellular matrix and leads to a visible wrinkle reduction in vivo. In conclusion, A. lappa fruit extract represents a targeted means to regenerate dermal structures and, thus, offers an effective treatment option for mature skin.
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